HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 71496744, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86721248 | HCID 86721248 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71496744 | HCID 71496744 | 93.3% |
Reaction Steps
A solution of the compound (780 mg, 2.10 mmol) obtained in step 13, HATU (958 mg, 2.52 mmol), DIEA (0.439 ml, 2.52 mmol) and (tetrahydro-2H-pyran-4-yl)methanamine (290 mg, 2.52 mmol) in DMF (10 mL) was stirred at room temperature for 14 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine and dried, and the solvent was evaporated under reduced pressure to give the title compound (918 mg, 1.959 mmol, 93%) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156837B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f4571591bcfb4841a4193c5d2f76d0e9 |
| Source note | uspto-grants-2015_10 |