4-(Trifluoromethyl)phenylboronic acid → HCID 86721249, compound

HRID 1750406Notes

Reaction equation

HRID 1750406 reaction equation
Br[C:2]1[N:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:18])[N:15]=1.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1>>[C:7]([N:6]1[C:2]([C:32]2[CH:33]=[CH:34][C:29]([C:28]([F:39])([F:38])[F:27])=[CH:30][CH:31]=2)=[C:3]([C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:18])[N:15]=2)[CH:4]=[N:5]1)([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 86721244HCID 86721244, compound

Product 1

HCID 86721249HCID 86721249, compound

Procedure

Using 2-(2-(5-bromo-1-tert-butyl-1H-pyrazol-4-yl)thiazol-4-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide and 4-(trifluoromethyl)phenylboronic acid and by reaction and purification in the same manner as in the method described in Example 30, step 9, the title compound was obtained. MS (API): 507 (M+H)

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-ea2dfd4e781146cead2b8608a178d81a
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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