4-Aminomethyltetrahydropyran → HCID 86721252, compound

HRID 1750408Notes

Reaction equation

[C:1]([N:5]1[C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:8]([C:18]2[S:19][CH:20]=[C:21]([CH2:23][C:24](O)=[O:25])[N:22]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[O:27]1[CH2:32][CH2:31][CH:30]([CH2:33][NH2:34])[CH2:29][CH2:28]1>>[C:1]([N:5]1[C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:8]([C:18]2[S:19][CH:20]=[C:21]([CH2:23][C:24]([NH:34][CH2:33][CH:30]3[CH2:31][CH2:32][O:27][CH2:28][CH2:29]3)=[O:25])[N:22]=2)[CH:7]=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 86721253HCID 86721253, compound

Product 1

HCID 86721252HCID 86721252, compound

Procedure

Using the compound obtained in step 4 and (tetrahydro-2H-pyran-4-yl)methanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-8958a46670654757b5b2515aa687b37d
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156837B2

Reaction notes

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