4-Aminomethyltetrahydropyran → HCID 86721256, compound

HRID 1750411Notes

Reaction equation

[C:1]([N:5]1[C:9]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)=[C:8]([C:20]2[S:21][CH:22]=[C:23]([CH2:25][C:26](O)=[O:27])[N:24]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[O:29]1[CH2:34][CH2:33][CH:32]([CH2:35][NH2:36])[CH2:31][CH2:30]1>>[C:1]([N:5]1[C:9]([CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=2)=[C:8]([C:20]2[S:21][CH:22]=[C:23]([CH2:25][C:26]([NH:36][CH2:35][CH:32]3[CH2:33][CH2:34][O:29][CH2:30][CH2:31]3)=[O:27])[N:24]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 86721257HCID 86721257, compound

Product 1

HCID 86721256HCID 86721256, compound

Procedure

Using the compound obtained in step 5 and (tetrahydro-2H-pyran-4-yl)methanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-f9feb3bbc082401590cf5976eff0a5fa
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156837B2

Reaction notes

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