4-Aminomethyltetrahydropyran → HCID 90184693, compound

HRID 1750413Notes

Reaction equation

HRID 1750413 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH3:15])[CH3:14])[N:11]=[CH:10][C:9]=2[C:16]2[S:17][CH:18]=[C:19]([CH2:21][C:22](O)=[O:23])[N:20]=2)=[CH:4][CH:3]=1.[O:25]1[CH2:30][CH2:29][CH:28]([CH2:31][NH2:32])[CH2:27][CH2:26]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH:13]([CH3:15])[CH3:14])[N:11]=[CH:10][C:9]=2[C:16]2[S:17][CH:18]=[C:19]([CH2:21][C:22]([NH:32][CH2:31][CH:28]3[CH2:29][CH2:30][O:25][CH2:26][CH2:27]3)=[O:23])[N:20]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27732104-AminomethyltetrahydropyranHCID 90184719HCID 90184719, compound

Product 1

HCID 90184693HCID 90184693, compound

Procedure

Using the compound obtained in step 4 and (tetrahydro-2H-pyran-4-yl)methanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-e0d0d05016dc4453af8ed711681eb4bd
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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