Ammonia → HCID 86721258, compound

Participants

Reaction Steps

A solution of 1-cyclohexyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid (300 mg, 1.04 mmol) and thionyl chloride (0.379 mL, 5.20 mmol) in toluene (3 mL) was stirred at 90° C. for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in THF (3 mL). 28% Aqueous ammonia (2 mL, 22.87 mmol) was added to the THF solution, and the mixture was stirred at room temperature for 14 hr. The reaction mixture was poured into water, and the precipitate was collected by filtration to give 1-cyclohexyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (284 mg, 0.988 mmol, 95%) as a white powder.

Provenance & Evidence