Lawesson's reagent → HCID 86721260, compound

Participants

Reaction Steps

A solution of the compound (284 mg, 0.99 mmol) obtained in step 1 and Lawesson's reagent (360 mg, 0.89 mmol) in THF (4 mL) was stirred at 60° C. for 30 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by NH-silica gel column chromatography (solvent gradient; 5→95% ethyl acetate/hexane) to give 1-cyclohexyl-5-(4-fluorophenyl)-1H-pyrazole-4-carbothioamide (236 mg, 0.778 mmol, 79%) as a white powder.

Provenance & Evidence