Ethyl 4-chloroacetoacetate → HCID 86721261, compound

Participants

Reaction Steps

A solution of the compound (236 mg, 0.78 mmol) obtained in step 2 and ethyl 4-chloroacetoacetate (0.126 ml, 0.93 mmol) in ethanol (4 mL) was stirred at 90° C. for 18 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from hexane to give ethyl 2-(2-(1-cyclohexyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetate (269 mg, 0.651 mmol, 84%) as a white powder.

Provenance & Evidence