Sodium Hydroxide → HCID 86721262, compound

Participants

Reaction Steps

A mixed solution of the compound (269 mg, 0.65 mmol) obtained in step 3 and 1N aqueous sodium hydroxide solution (0.976 mL, 0.98 mmol) in ethanol (4 mL) and THF (4 mL) was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. 1N Hydrochloric acid was added thereto, and the precipitate was collected by filtration, and crystallized from diethyl ether and hexane to give 2-(2-(1-cyclohexyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (226 mg, 0.586 mmol, 90%) as a white powder.

Provenance & Evidence