HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 71494103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86721262 | HCID 86721262 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 71494103 | HCID 71494103 | 71.9% |
Reaction Steps
A solution of the compound (50 mg, 0.13 mmol) obtained in step 4, HATU (74.0 mg, 0.19 mmol), DIEA (0.034 ml, 0.19 mmol) and (tetrahydro-2H-pyran-4-yl)methanamine (0.022 ml, 0.19 mmol) in DMF (2 mL) was stirred at room temperature for 2 days. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried, and the solvent was evaporated under reduced pressure. The obtained residue was crystallized from ethyl acetate and hexane to give the title compound (45 mg, 0.093 mmol, 71.9%) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156837B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-7e7d9fb966724c4ca672037166d687ad |
| Source note | uspto-grants-2015_10 |