4-Aminomethyltetrahydropyran → HCID 90184603, compound

HRID 1750419Notes

Reaction equation

[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH3:13])=[C:5]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][C:20](O)=[O:21])[N:18]=2)[CH:4]=[N:3]1.[O:23]1[CH2:28][CH2:27][CH:26]([CH2:29][NH2:30])[CH2:25][CH2:24]1>>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH3:13])=[C:5]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][C:20]([NH:30][CH2:29][CH:26]3[CH2:27][CH2:28][O:23][CH2:24][CH2:25]3)=[O:21])[N:18]=2)[CH:4]=[N:3]1

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 90184588HCID 90184588, compound

Product 1

HCID 90184603HCID 90184603, compound

Procedure

Using the compound obtained in step 3 and (tetrahydro-2H-pyran-4-yl)methanamine and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record: ord-a341852dcd554a28abefd57f6fac183d
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156837B2

Reaction notes

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