4-Isopropoxybenzeneboronic acid → HCID 71250776, compound

HRID 1750420Notes

Reaction equation

HRID 1750420 reaction equation
Br[C:2]1[N:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:18])[N:15]=1.[CH:27]([O:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1)([CH3:29])[CH3:28]>>[C:7]([N:6]1[C:2]([C:34]2[CH:35]=[CH:36][C:31]([O:30][CH:27]([CH3:29])[CH3:28])=[CH:32][CH:33]=2)=[C:3]([C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:18])[N:15]=2)[CH:4]=[N:5]1)([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 36987264-Isopropoxybenzeneboronic acidHCID 86721244HCID 86721244, compound

Product 1

HCID 71250776HCID 71250776, compound

Procedure

Using 2-(2-(5-bromo-1-tert-butyl-1H-pyrazol-4-yl)thiazol-4-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide and (4-isopropoxyphenyl)boronic acid and by reaction and purification in the same manner as in the method described in Example 43, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-491be9f93f06417ab66e3b348df83f46
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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