(4-(Morpholin-4-yl)phenyl)boronic acid → HCID 86721263, compound

HRID 1750421Notes

Reaction equation

HRID 1750421 reaction equation
Br[C:2]1[N:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:18])[N:15]=1.[O:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=2)[CH2:29][CH2:28]1>>[C:7]([N:6]1[C:2]([C:36]2[CH:35]=[CH:34][C:33]([N:30]3[CH2:29][CH2:28][O:27][CH2:32][CH2:31]3)=[CH:38][CH:37]=2)=[C:3]([C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:18])[N:15]=2)[CH:4]=[N:5]1)([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 2795359(4-(Morpholin-4-yl)phenyl)boronic acidHCID 86721244HCID 86721244, compound

Product 1

HCID 86721263HCID 86721263, compound

Procedure

Using 2-(2-(5-bromo-1-tert-butyl-1H-pyrazol-4-yl)thiazol-4-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide and (4-morpholinophenyl)boronic acid and by reaction and purification in the same manner as in the method described in Example 43, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-f2603dfb52024ef3aeb41870313929da
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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