(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acid → HCID 86721264, compound

HRID 1750422Notes

Reaction equation

HRID 1750422 reaction equation
Br[C:2]1[N:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:18])[N:15]=1.[O:27]1[CH2:32][CH2:31][O:30][C:29]2[CH:33]=[C:34](B(O)O)[CH:35]=[CH:36][C:28]1=2>>[C:7]([N:6]1[C:2]([C:34]2[CH:35]=[CH:36][C:28]3[O:27][CH2:32][CH2:31][O:30][C:29]=3[CH:33]=2)=[C:3]([C:11]2[S:12][CH:13]=[C:14]([CH2:16][C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)=[O:18])[N:15]=2)[CH:4]=[N:5]1)([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 2776178(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acidHCID 86721244HCID 86721244, compound

Product 1

HCID 86721264HCID 86721264, compound

Procedure

Using 2-(2-(5-bromo-1-tert-butyl-1H-pyrazol-4-yl)thiazol-4-yl)-N-((tetrahydro-2H-pyran-4-yl)methyl)acetamide and (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)boronic acid and by reaction and purification in the same manner as in the method described in Example 43, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-5ef7fddcf0444bf9ac9e7138a84b357c
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

Loading…