Lawesson's reagent → HCID 86721266, compound

Participants

Reaction Steps

A solution of the mixture (711 mg, 2.33 mmol) obtained in step 5 and Lawesson's reagent (754 mg, 1.86 mmol) in THF (10 mL) was stirred at 60° C. for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was treated with ethyl acetate and diethyl ether to give a mixture (415 mg, 55%) of tert-butyl 4-carbamothioyl-5-(4-fluorophenyl)-1H-pyrazole-1-carboxylate and tert-butyl 4-carbamothioyl-3-(4-fluorophenyl)-1H-pyrazole-1-carboxylate as a yellow powder.

Provenance & Evidence