Sodium Hydroxide → HCID 86721269, compound

Participants

Reaction Steps

To a solution of the compound (178 mg, 0.537 mmol) obtained in step 7 in ethanol (2.2 mL) was added 6N aqueous sodium hydroxide solution (0.269 mL, 1.61 mmol) at room temperature, and the mixture was heated under reflux for 1 hr. The organic solvent was evaporated, and 2N hydrochloric acid was added until the mixture became pH2. The precipitate was collected by filtration to give {2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetic acid (122 mg, 75%) as a yellow powder.

Provenance & Evidence