Sodium Hydroxide → 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoic acid

Participants

Reaction Conditions

Reaction Steps

To a mixed solution of the compound (14 mg, 0.03 mmol) obtained in step 1 in ethanol (1.0 mL) and THF (1.0 mL) was added 1N aqueous sodium hydroxide solution (0.059 mL, 0.06 mmol) at room temperature, and the mixture was stirred at 60° C. for 3 hr. The reaction mixture was diluted with water, 1N hydrochloric acid was added until the mixture became pH 2-3, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure to give 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoic acid (11.4 mg, 0.025 mmol, 87%) as a colorless oil.

Provenance & Evidence