Ethyl bromopyruvate → HCID 86721278, compound

Participants

Reaction Steps

A solution of 1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carbothioamide (1.24 g, 4.28 mmol) and ethyl bromopyruvate (0.647 mL, 5.14 mmol) in ethanol (24 mL) was stirred at 90° C. for 14 hr. The reaction mixture was concentrated under reduced pressure, and hexane was added thereto to give ethyl 2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carboxylate (1.27 g, 3.29 mmol, 77%) as a white powder.

Provenance & Evidence