Sodium Sulfate → HCID 86721279, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (39.4 mg, 1.04 mmol) in THF (2.0 mL) was added a solution of the compound (200 mg, 0.52 mmol) obtained in step 1 in THF (2.0 mL) at 0° C., and the mixture was stirred at 0° C. for 2 hr. To the reaction mixture was added Na2SO4 10H2O (excess amount), and the mixture was stirred at room temperature for 30 min. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give crude (2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanol as a white solid, which was used for the next step without purification.

Provenance & Evidence