Water → HCID 86721280, compound

Participants

Reaction Steps

To a solution of the compound (663 mg, 1.93 mmol) obtained in step 2 and TEA (0.807 mL, 5.79 mmol) in DMSO (14 mL) was added a sulfur trioxide-pyridine complex (922 mg, 5.79 mmol) at room temperature, and the mixture was stirred at room temperature for 14 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent; ethyl acetate) to give 2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde (607.5 mg, 1.779 mmol, 92%) as a white powder.

Provenance & Evidence