HCID 86721287, compound → HCID 86721288, compound

Participants

Reaction Steps

A solution of the compound (13.6 mg, 0.03 mmol) obtained in step 1 in TFA (1.0 mL) was stirred at room temperature for 1 hr, and concentrated under reduced pressure. To the residue were added saturated aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic layer was dried, and the solvent was evaporated under reduced pressure to give (2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanamine (7.2 mg, 0.022 mmol, 69.0%) as a pale-yellow oil.

Provenance & Evidence