5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one → 6-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1750452Notes

Reaction equation

HRID 1750452 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22](O)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:25]1[C:34]2[CH2:33][CH2:32][NH:31][CH2:30][C:29]=2[CH:28]=[CH:27][C:26]1=[O:35]>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH2:19][CH:20]([C:22]([N:31]3[CH2:32][CH2:33][C:34]4[NH:25][C:26](=[O:35])[CH:27]=[CH:28][C:29]=4[CH2:30]3)=[O:23])[N:21]=2)[CH:7]=[N:6]1)([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-oneHCID 867212902-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid

Product 1

HCID 712507616-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

Procedure

Using 2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)-4,5-dihydrothiazole-4-carboxylic acid and 5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-564983da2cb248ba84f5fb347a8c730e
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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