5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one → 6-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

HRID 1750453Notes

Reaction equation

HRID 1750453 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23](O)=[O:24])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:26]1[C:35]2[CH2:34][CH2:33][NH:32][CH2:31][C:30]=2[CH:29]=[CH:28][C:27]1=[O:36]>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23]([N:32]3[CH2:33][CH2:34][C:35]4[NH:26][C:27](=[O:36])[CH:28]=[CH:29][C:30]=4[CH2:31]3)=[O:24])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 210711895,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-oneHCID 867211822-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid

Product 1

HCID 712507596-({2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}acetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one

Procedure

Using 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid and 5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-ff61f901f0054034aa3207c3b2da0685
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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