反应详情

Sodium borohydride (0.036 g, 0.954 mmol) was added to a solution of 2-{[5-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentan-1-one (0.116 g, 0.48 mmol) in ethanol (5 ml). The reaction was stirred at room temperature for 1 hour and then quenched with water (5 ml) and 2M HCl (aq, 5 ml), basified with 2M NaOH (aq) and extracted with ethyl acetate (2×30 ml). The combined organics were dried over dried over magnesium sulfate, filtered through a hydrophobic frit and concentrated in vacuo. The crude product was purified by column chromatography (silica, 0-30% ethyl acetate/petrol) to afford the title compound as two diastereomers.

1. customquenched with water (5 ml) and 2M HCl (aq, 5 ml)
2. extractionextracted with ethyl acetate (2×30 ml)
3. customThe combined organics were dried
4. dry with materialover dried over magnesium sulfate
5. filtrationfiltered through a hydrophobic frit
6. concentrationconcentrated in vacuo
7. customThe crude product was purified by column chromatography (silica, 0-30% ethyl acetate/petrol)