HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-6-methoxybenzoic acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-6-methoxybenzoic acid | HCID 2737360 | — |
| Reactant | (1S,2S)-trans-N-Boc-1,2-cyclopentanediamine | HCID 17040218 | — |
| Reactant | 1,3,5,2,4,6-Trioxatriphosphinane | HCID 20398195 | — |
| Reactant | N-[(1S,2S)-2-Aminocyclopentyl]-2-chlorobenzamide hydrochloride | HCID 118308080 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | N-[(1S,2S)-2-Aminocyclopentyl]-2-fluoro-6-methoxybenzamide hydrochloride | HCID 118308173 | — |
Reaction Steps
Prepared according to the procedure for N-[(1S,2S)-2-aminocyclopentyl]-2-chlorobenzamide hydrochloride (Intermediate 19) from tert-butyl N-[(1S,2S)-2-aminocyclopentyl]carbamate (CAS number 586961-34-4; 500 mg, 2.50 mmol), 2-fluoro-6-methoxybenzoic acid (CAS number 137654-21-8; 637 mg, 3.74 mmol) and 1,3,5,2,4,6-trioxatriphosphorinane, 2,4,6-tripropyl-, 2,4,6-trioxide (CAS number 68957-94-8; 50% in ethyl acetate, 2.2 ml, 3.74 mmol). Subsequent deprotection with HCl afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156829B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-10a25820505e48a9a88e10d87de09b71 |
| Source note | uspto-grants-2015_10 |