反应详情

A solution of (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl N-(2-amino-2-methylcyclopentyl)carbamate hydrochloride (Intermediate 27; 1.50 g, 4.51 mmol), 2-fluoro-5-(trifluoromethyl)pyridine (CAS number 69045-82-5; 0.652 mL, 5.41 mmol) and DIPEA (2.36 ml, 13.5 mmol) in DMSO (10 ml) was subjected to microwave irradiation at 140° C. for 4 hours. The reaction was diluted with ethyl acetate (200 ml) and a saturated solution of sodium bicarbonate (100 ml). The aqueous layer was further extracted with ethyl acetate (100 ml). The combined organics were washed with water (50 ml), brine (50 ml), dried over magnesium sulfate, filtered through a hydrophobic frit and concentrated in vacuo. The crude product was purified by column chromatography (silica, 10-20% diethyl ether/petrol) to afford the title compound as a single trans-enantiomer.

1. customirradiation at 140° C. for 4 hours
2. extractionThe aqueous layer was further extracted with ethyl acetate (100 ml)
3. washThe combined organics were washed with water (50 ml), brine (50 ml)
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered through a hydrophobic frit
6. concentrationconcentrated in vacuo
7. customThe crude product was purified by column chromatography (silica, 10-20% diethyl ether/petrol)