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HRID1750596

反应详情

EQUATION

反应方程式

HRID 1750596 的结构方程式

REACTANTS

反应物

3
结构：CCOc1ccc(C)cc1C(=O)O
HCID18954602

未命名化合物

结构：Cl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308118

未命名化合物

2 次

结构：O=C(N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1)c1ncccc1Br
HCID118308278

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1ccc(C)cc1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308061

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure for 3-bromo-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]pyridine-2-carboxamide (Example 28) from (1S,2S)-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 14, 75 mg, 0.27 mmol) and 2-ethoxy-5-methylbenzoic acid (CAS number 854645-34-4; 57 mg, 0.32 mmol) and was then purified by column chromatography (silica, 40-100% ethyl acetate/petrol) to afford the title compound.

WORKUP

后处理

  1. customPrepared
  2. customwas then purified by column chromatography (silica, 40-100% ethyl acetate/petrol)