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HRID1750602

反应详情

EQUATION

反应方程式

HRID 1750602 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)c1ccccc1-n1ccnn1
HCID23023763

2-(1H-1,2,3-Triazol-1-yl)benzoic acid

C9H7N3O2

结构：Cl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308118

未命名化合物

2 次

结构：O=C(N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1)c1ccccc1-n1cccn1
HCID118308230

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1)c1ccccc1-n1ccnn1
HCID118308054

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure for 2-(1H-pyrazol-1-yl)-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]benzamide (Example 31) from (1S,2S)-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 14, 213 mg, 0.75 mmol) and 2-(1H-1,2,3-triazol-1-yl)benzoic acid (CAS number 1085458-53-2; 157 mg, 0.83 mmol) except this was then purified by column chromatography (silica, 0-100% ethyl acetate/petrol) to afford the title compound.

WORKUP

后处理

  1. customPrepared
  2. customthis was then purified by column chromatography (silica, 0-100% ethyl acetate/petrol)