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HRID1750615

反应详情

EQUATION

反应方程式

HRID 1750615 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(-n2cccn2)c(C(=O)O)c1
HCID62514431

未命名化合物

结构：Cl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308118

未命名化合物

2 次

结构：COc1ccc(C)cc1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308274

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc(-n2cccn2)c(C(=O)N[C@H]2CCC[C@@H]2Nc2cnc(C(F)(F)F)cn2)c1
HCID118308251

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure for 2-methoxy-5-methyl-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]benzamide (Example 37) from (1S,2S)-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 14; 75 mg, 0.27 mmol) and 5-methyl-2-(1H-pyrazol-1-yl)benzoic acid (CAS number 1214622-46-4; 74 mg, 0.37 mmol) except this was purified by column chromatography (silica, 40-100% ethyl acetate/petrol) to afford the title compound.

WORKUP

后处理

  1. customPrepared
  2. customthis was purified by column chromatography (silica, 40-100% ethyl acetate/petrol)