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HRID1750616

反应详情

EQUATION

反应方程式

HRID 1750616 的结构方程式

REACTANTS

反应物

3
结构：COc1cccc(Br)c1C(=O)O
HCID11117881

2-BROMO-6-METHOXYBENZOIC ACID

C8H7BrO3

结构：Cl.N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308118

未命名化合物

2 次

结构：COc1ccc(C)cc1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308274

未命名化合物

PRODUCTS

生成物

1
结构：COc1cccc(Br)c1C(=O)N[C@H]1CCC[C@@H]1Nc1cnc(C(F)(F)F)cn1
HCID118308087

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure for 2-methoxy-5-methyl-N-[(1S,2S)-2-{[5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]benzamide (Example 37) from (1S,2S)-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 14; 250 mg, 0.88 mmol) and 2-bromo-6-methoxybenzoic acid (CAS number 31786-45-5; 245 mg, 1.06 mmol) except this was purified by column chromatography (silica, 0-100% ethyl acetate/petrol) to afford the title compound.

WORKUP

后处理

  1. customPrepared
  2. customthis was purified by column chromatography (silica, 0-100% ethyl acetate/petrol)