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HRID1750645

反应详情

EQUATION

反应方程式

HRID 1750645 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)c1ccccc1-n1nccn1
HCID21313592

2-(2H-1,2,3-Triazol-2-yl)benzoic acid

C9H7N3O2

结构：CN(c1cnc(C(F)(F)F)cn1)[C@H]1CCC[C@@H]1N.Cl
HCID118308127

未命名化合物

2 次

结构：Cc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)c1ncccc1-n1nccn1
HCID118308165

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc(C(F)(F)F)cnc1N[C@H]1CCC[C@@H]1NC(=O)c1ccccc1-n1nccn1
HCID118308298

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure for N-[(1S,2S)-2-{[3-methyl-5-(trifluoromethyl)pyrazin-2-yl]amino}cyclopentyl]-3-(2H-1,2,3-triazol-2-yl)pyridine-2-carboxamide (Example 76) from (1S,2S)-1-N-methyl-1-N-[5-(trifluoromethyl)pyrazin-2-yl]cyclopentane-1,2-diamine hydrochloride (Intermediate 23; 60 mg, 0.20 mmol) and 2-(2H-1,2,3-triazol-2-yl)benzoic acid (CAS number 1001401-62-2; 40 mg, 0.21 mmol) except this was purified only by column chromatography (silica, 0 to 100% ethyl acetate/petrol) to afford the title compound.

WORKUP

后处理

  1. customPrepared
  2. customthis was purified only by column chromatography (silica, 0 to 100% ethyl acetate/petrol)