HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750684Generated: November 1, 2026
2-Bromo-4-(trifluoromethyl)pyridine → 2-(2H-1,2,3-Triazol-2-yl)-N-[(1S,2S)-2-{[4-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]benzamide
https://huagongshe.com/reaction/1750684
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromo-4-(trifluoromethyl)pyridine | HCID 2781543 | — |
| Reactant | N-[(1S,2S)-2-Aminocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride | HCID 118025476 | — |
| Reactant | N-[(1S,2S)-2-[(5-Bromopyridin-2-yl)amino]cyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide | HCID 118308185 | — |
| Product | 2-(2H-1,2,3-Triazol-2-yl)-N-[(1S,2S)-2-{[4-(trifluoromethyl)pyridin-2-yl]amino}cyclopentyl]benzamide | HCID 118308129 | — |
Reaction Steps
Prepared according to the procedure for N-[(1S,2S)-2-[(5-bromopyridin-2-yl)amino]cyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide (Example 118) from N-[(1S,2S)-2-aminocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride (Intermediate 4; 200 mg, 0.65 mmol) and 2-bromo-4-(trifluoromethyl)pyridine (CAS number 175205-81-9; 147 mg, 0.650 mmol) except this was heated to 140° C. for 17 hours to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09156829B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-a7991aac84be4bd7a93ef7f9b77d3596 |
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| Source note | uspto-grants-2015_10 |
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