HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 58080194, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | (3R)-3-Amino-N,N-dimethyl-4-(phenylsulfanyl)butanamide | HCID 59803658 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58080194 | HCID 58080194 | — |
Reaction Steps
A solution of Example 1C (8.68 g) in THF (200 mL) was treated with BH3-dimethylsulfide (18.2 mL) at room temperature, stirred overnight, treated slowly with methanol (20 mL), followed by 2N HCl (50 mL), stirred overnight, and concentrated. The resulting residue was purified by silica gel chromatography eluting with 5% 7N NH3/CH3OH in dichloromethane to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156856B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f2bd9599590d4486bbf27678f7a0cb43 |
| Source note | uspto-grants-2015_10 |