HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl bromide → Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl bromide | HCID 76965 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate | HCID 16109102 | — |
Reaction Steps
A solution of Example 4A (23.43 g, 100.0 mmol), 2-bromobenzyl bromide (26.24 g, 105.0 mmol) and diisopropylethylamine (20.94 mL, 120.0 mmol) in acetonitrile (200 mL) was stirred at room temperature for two hours. The resulting precipitate was collected by filtration to give the desired product, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156856B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-c6ca4aa9caf348d09eed9f7b90a67c24 |
| Source note | uspto-grants-2015_10 |