Ammonium Hydroxide → N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

2-Acetamido-4-methylthiazole-5-sulfonyl chloride (0.50 g, 1.96 mmol) was dissolved in THF (7 mL), cooled to 0° C., and concentrated NH4OH (0.7 mL) was added. After 3 hours the reaction was concentrated, diluted with water, and extracted with CHCl3/methanol. The organic layer was dried over Na2SO4. Filtration and concentration gave the product that was used Example 11B.

Provenance & Evidence