HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 67145179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 5-Hydroxyindole | HCID 16054 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | HCID 67145179 | HCID 67145179 | — |
Reaction Steps
Ethyl 2,4-difluorobenzoate (12.75 g), K3PO4 (14.54 g) and 5-hydroxyindole (9.12 g) were stirred at 110° C. in diglyme (125 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and brine, and dried. The solution was then concentrated, and the crude product was poured into hexanes, stirred, and filtered to give the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156856B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-b1b69a82d9a74bc09b733a346b4fedea |
| Source note | uspto-grants-2015_10 |