HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750740Generated: October 31, 2026
2-Iodobenzylic alcohol → 2-(4-Chlorophenyl)benzyl alcohol
https://huagongshe.com/reaction/1750740
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Iodobenzylic alcohol | HCID 107629 | — |
| Reactant | 4'-Chlorobiphenyl-2-boronic acid | HCID 23450998 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-Chlorophenyl)benzyl alcohol | HCID 1392780 | — |
Reaction Steps
A mixture of 2-iodobenzyl alcohol (11.0 g), 4-chlorophenylbenzeneboronic acid (8.5 g), and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (800 mg) in Na2CO3 (2M solution, 94 mL) and dioxane (300 mL) was heated to 80° C. for 24 hours. The mixture was cooled, the layers were separated, and the organic layer was condensed. The resulting residue was purified by silica gel chromatography eluting with 20% ethyl acetate in hexanes to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09156856B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-7ee65dd410d74e2ab8bb4295062cb0ae |
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| Source note | uspto-grants-2015_10 |
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