HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750818Generated: October 31, 2026
Sodium Carbonate → 1,2,3-Trifluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene
https://huagongshe.com/reaction/1750818
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-Propene, 2-bromo-3,3,3-trifluoro- | HCID 272696 | — |
| Reactant | (3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride) | HCID 2734671 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 1,2,3-Trifluoro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene | HCID 86685070 | — |
Reaction Steps
A mixture of (3,4,5-trifluorophenyl)boronic acid (0.5 g, 2.84 mmol), 2-bromo-3,3,3-trifluoroprop-1-ene (596 mg, 3.41 mmol, 1.2 eq), Na2CO3 (0.90 g, 8.52 mmol, 3 eq) and Pd(dppf)Cl2 (232 mg, 10% mol) in DME (20 mL) and water (2 mL) was heated at 70 to 80° C. for 2 h. The mixture was cooled to 0° C. with ice-water bath, and then used to next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09156860B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-2bbd38e76ad24c698311b733d2331130 |
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| Source note | uspto-grants-2015_10 |
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