HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750867Generated: October 31, 2026
Azobisisobutyronitrile → 1-(Bromomethyl)-4-nitro-2-(trifluoromethyl)benzene
https://huagongshe.com/reaction/1750867
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Methyl-5-nitrobenzotrifluoride | HCID 2775447 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 1-(Bromomethyl)-4-nitro-2-(trifluoromethyl)benzene | HCID 46838761 | 98.1% |
Reaction Steps
1-methyl-4-nitro-2-(trifluoromethyl)benzene (25 g, 122 mmol) was dissolved in dichloroethane (300 mL), followed by stirring. NBS (21.7 g, 122 mmol) and AIBN (2.0 g, 12.2 mmol) were added thereto, followed by further stirring for about 12 hours at 80° C. The resulting solid was filtered under reduced pressure, and dried with warm wind in an oven (40° C.) for 3 hours or more to obtain the title compound (34 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09156852B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-3f352ea0510b4de4bc1cd7bf42ee0177 |
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| Source note | uspto-grants-2015_10 |
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