HCID 67970285, compound → HCID 71622860, compound

HRID 1750869Notes

Reaction equation

[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[C:23]([CH3:24])=[CH:22][CH:21]=[C:20]4[C:15]=3[CH:16]=[CH:17][N:18]=[C:19]4[NH:25][C:26]3[CH:31]=[CH:30][C:29]([CH2:32][N:33]4[CH2:38][CH2:37][N:36]([CH2:39][CH3:40])[CH2:35][CH2:34]4)=[C:28]([C:41]([F:44])([F:43])[F:42])[CH:27]=3)=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:45]NC1C2SC=C(C(O)=O)C=2N=CN=1>>[CH2:39]([N:36]1[CH2:35][CH2:34][N:33]([CH2:32][C:29]2[CH:30]=[CH:31][C:26]([NH:25][C:19]3[C:20]4[C:15](=[C:14]([NH:13][C:11]([C:8]5[C:4]6[N:5]=[CH:6][N:7]=[C:2]([NH:1][CH3:45])[C:3]=6[S:10][CH:9]=5)=[O:12])[C:23]([CH3:24])=[CH:22][CH:21]=4)[CH:16]=[CH:17][N:18]=3)=[CH:27][C:28]=2[C:41]([F:43])([F:44])[F:42])[CH2:38][CH2:37]1)[CH3:40]

Participants

Reactant 2

HCID 67970285HCID 67970285, compound

HCID 71622720HCID 71622720, compound

Product 1

HCID 71622860HCID 71622860, compoundYield 13%

Procedure

The procedures of <Step 3> of Example 1 were repeated in sequence, except for using N1-(4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl)-6-methyl-isoquinolin-1,5-diamine (0.020 g, 0.05 mmol) obtained in Example 7 and 4-methylamino-thieno[3,2-d]pyrimidine-7-carboxylic acid (see WO 2011009687, 0.05 mmol) to obtain the title compound (4 mg, 13%).

Sources & evidence

ORD record: ord-a6ea4a460574437ea12346bfb81e5cd9
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09156852B2

Reaction notes

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