Formamide → 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one

Participants

Reaction Conditions

Reaction Steps

3-amino-4-methyl-thiophene-2-carboxylic acid methyl ester (10.2 g, 59.6 mmol) was dissolved in formamide (25 mL), followed by refluxing for 24 hours at 200° C. The reaction solution was slowly cooled to room temperature. The resulting solid was filtered, washed with diethyl ether, and dried to obtain the title compound (9 g, 91%).

Provenance & Evidence