Sodium Hydroxide → HCID 89655921, compound

HRID 1750877Notes

Reaction equation

HRID 1750877 reaction equation
C([O:4][CH2:5][C:6]1[C:10]2[N:11]=[CH:12][N:13]=[CH:14][C:9]=2[S:8][CH:7]=1)(=O)C.[OH-].[Na+]>O1CCCC1.O>[OH:4][CH2:5][C:6]1[C:10]2[N:11]=[CH:12][N:13]=[CH:14][C:9]=2[S:8][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 89655329HCID 89655329, compound

Product 1

HCID 89655921HCID 89655921, compoundYield 80.9%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

7-acetyloxymethyl-thieno[3,2-d]pyrimidine (134 mg, 0.64 mmol) was dissolved in tetrahydrofuran/water (2 mL/2 mL), added with an aqueous solution of 1 N sodium hydroxide (0.97 mL, 0.97 mmol), followed by stirring for 2 hours at room temperature. The reaction solution was subjected to extraction with ethyl acetate, dried, and filtered to obtain the title compound (86 mg, 77%).

Workup

  1. extractionThe reaction solution was subjected to extraction with ethyl acetate
  2. customdried
  3. filtrationfiltered

Sources & evidence

ORD record
ord-46d519d7ec4643a98f6ef17903e02371
Source dataset
uspto-grants-2015_10
Patent number
US09156852B2

Reaction notes

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