Dimethylformamide → HCID 58046775, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.2 g, 0.43 mmol) and potassium carbonate (0.089 g, 0.65 mmol) in N,N-dimethylformamide (4 mL), was added 2-chloro-N,N-diethylacetamide (0.059 g, 0.43 mmol, d=1.089). After stirring at 55° C. for 18 hours, the reaction mixture was diluted with ethyl acetate (25 mL), washed with dilute citric acid, water and brine. The organic phase was dried over MgSO4, filtered and isolated by Biotage flash chromatography to obtain the title compound (0.22 g, 88%); MS for C32H42N4O6 m/z 579.10 (M+H)+.

Provenance & Evidence