反应详情

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

1. customAfter the reaction
2. customthe insoluble matter was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customto obtain the entitled compound
5. customNot purified
6. customthis was used in the next reaction as such