Hydrochloric Acid → HCID 58046751, compound

Participants

Reaction Steps

To tert-butyl 3-((4-oxo-8-(4-oxo-4-phenylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate (0.1 g, 0.18 mmol) was added 4M solution of HCl in dioxane (2 mL) and triethylsilane (0.1 mL). After stirring at room temperature for 4 hours, the reaction mixture was concentrated in vacuo and isolated by reverse phase HPLC to obtain the title compound as an acetate salt (0.044 g, 43%); 1H NMR (DMSO-d6): δ 1.58 (d, 2H, J=13.6 Hz), 1.84 (t, 2H, J=6.8 Hz), 2.42-2.53 (m, 4H), 2.74-2.78 (m, 4H), 3.05 (t, 2H, J=7.2 Hz), 4.58 (d, 4H, J=13.2 Hz), 6.70-6.75 (m, 3H), 7.12 (t, 2H, J=7.2 Hz), 7.48-7.54 (m, 3H), 7.63 (t, 2H, J=7.6 Hz), 7.85 (d, 2H, J=2 Hz), 7.98 (dd, 2H, J=8 and 1.6 Hz); MS for C31H33N3O4 m/z 512.07 (M+H)+.

Provenance & Evidence