Nitric Acid → HCID 131733613, compound

HRID 1751167Notes

Reaction equation

HRID 1751167 reaction equation
[OH-].[Na+].[C:3]([CH2:8][C:9]([O:11]CC)=[O:10])(=[O:7])[CH2:4][CH2:5][CH3:6].[N+]([O-])(O)=[O:15].[N+]([O-])([O-])=O.[Cu+2:22].[N+]([O-])([O-])=O>>[OH2:7].[OH2:15].[C:3]([CH2:8][C:9]([O-:11])=[O:10])(=[O:7])[CH2:4][CH2:5][CH3:6].[Cu+2:22].[C:3]([CH2:8][C:9]([O-:11])=[O:10])(=[O:7])[CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 18616Cupric nitrateHCID 238498Ethyl 3-oxohexanoate

Product 1

HCID 131733613HCID 131733613, compound

Conditions

Temperature
30 °C

Procedure

Into a NaOH aqueous solution (3.46 g, 24.0 mL) for hydrolysis, 11.4 g (72.0 mmol) of ethyl butyrylacetate was added, and stirred under heating at 30° C. for 3 hours. After the three hours, the reaction mixture was cooled down to 0° C., and a 5 N HNO3 aqueous solution as added thereto to make the reaction liquid acidic. To the reaction mixture, 4.34 g (7.20 mmol) of a copper (II) nitrate aqueous solution was added dropwise, and subjected to magnetic stirring for 3 hours. The precipitated solid was taken out by filtration, and washed with ion-exchanged water and acetone to obtain 4.37 g (12.2 mmol) of copper (II) butyrylacetate dihydrate in the form of blue solid.

Workup

  1. additionwas added
  2. temperatureAfter the three hours, the reaction mixture was cooled down to 0° C.
  3. customthe reaction liquid acidic
  4. stirringto magnetic stirring for 3 hours
  5. filtrationThe precipitated solid was taken out by filtration
  6. washwashed with ion-exchanged water and acetone

Sources & evidence

ORD record
ord-88119230168941a2a46bb2f48e03e9c0
Source dataset
uspto-grants-2015_10
Patent number
US09157004B2

Reaction notes

Loading…