反应详情

57 g (0.25 mol) of 2-[1-(3,3-dimethyl-cyclohexyl)-ethoxy]-2-methyl-propan-1-ol, 41.6 g (0.4 mol) of methoxyacetic acid methyl ester and 0.3 g of sodium methylate in 50 g methanol were placed in a 250-ml stirred vessel and were boiled under reflux. During this, methanol was distilled off via a still head. Then 100 ml water and 100 ml toluene were added to the reaction solution at room temperature, the aqueous phase was separated, the organic phase was washed with water until neutral and concentrated by evaporation. The raw product (81 g) was fractionated on a 30-cm Vigreux column in vacuum.

1. temperatureunder reflux
2. distillationDuring this, methanol was distilled off via a still head
3. additionThen 100 ml water and 100 ml toluene were added to the reaction solution at room temperature
4. customthe aqueous phase was separated
5. washthe organic phase was washed with water until neutral and
6. concentrationconcentrated by evaporation