Water → HCID 67515461, compound

Participants

Reaction Steps

53.5 g (0.25 mol) of hydroxyacetic acid-1-(3,3-dimethyl-cyclohexyl)-ethyl ester and 25.7 g (0.325 mol) of pyridine in 100 ml MTBE were placed in a 500-ml stirred vessel. Then 28.1 g (0.26 mol) of methoxyacetic acid chloride was added dropwise at room temperature, with cooling. Then 100 ml water and 100 ml toluene were added to the reaction solution at room temperature, the aqueous phase was separated, the organic phase was washed with dilute sulfuric acid, soda solution and water until neutral and concentrated by evaporation. The raw product (73 g) was fractionated on a 30-cm Vigreux column in vacuum.

Provenance & Evidence