Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Morpholinoethanol | HCID 61163 | — |
| Reactant | 2,2-Bis(trifluoromethyl)propionyl fluoride | HCID 2736187 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58855417 | HCID 58855417 | 70% |
Reaction Steps
A mixture of 26.2 g of 2-morpholinoethanol, 21.2 g of 2,2-bis(trifluoromethyl)propionic acid fluoride, 20.2 g of triethylamine, and 100 g of acetonitrile was stirred at 60° C. for 20 hours. This was followed by conventional aqueous work-up and purification by silica gel column chromatography. There was obtained 22.6 g of 2-morpholinoethyl 2,2-bis(trifluoromethyl)propionate (yield 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09158191B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-f7e9ff33c1cf41c39990cddf855ab919 |
|---|
| Source note | uspto-grants-2015_10 |
|---|
