Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester → HCID 58855397, compound

HRID 1751316Notes

Reaction equation

HRID 1751316 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH:8]([OH:24])[CH2:9][O:10][CH2:11][C:12]([F:23])([F:22])[C:13]([F:21])([F:20])[C:14]([F:19])([F:18])[CH:15]([F:17])[F:16])[CH2:3][CH2:2]1.[CH3:25][C:26](OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=[O:27]>>[C:26]([O:24][CH:8]([CH2:9][O:10][CH2:11][C:12]([F:22])([F:23])[C:13]([F:21])([F:20])[C:14]([F:18])([F:19])[CH:15]([F:16])[F:17])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)(=[O:27])[CH3:25]

Participants

3

Reactant 2

HCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 58855409HCID 58855409, compound

Product 1

HCID 58855397HCID 58855397, compoundYield 273.1%

Conditions

Temperature
50 °C

Procedure

To 37.5 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol was added 11.2 g of acetic anhyride. The mixture was stirred at 50° C. for 10 hours, followed by conventional aqueous work-up and purification by silica gel column chromatography. There was obtained 39.6 g of 2-morpholino-1-{(2,2,3,3,4,4,5,5-octafluoropentyloxy)-methyl}ethyl acetate (yield 95%).

Workup

  1. customfollowed by conventional aqueous work-up and purification by silica gel column chromatography

Sources & evidence

ORD record
ord-393f4090994341e4a2416644177cd515
Source dataset
uspto-grants-2015_10
Patent number
US09158191B2

Reaction notes

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